Journal of Comparative Effectiveness Research · 2018 · 13 citations · 37 references
MedicinePharmacologyPharmacotherapyClinical PharmacologyMeta-analysisPsychopharmacologyAntipsychotic PharmacologyAntipsychotic PharmacotherapyAntipsychotic TherapyDrug Efficacy AssessmentNetwork Meta-analysisSchizophrenia PharmacotherapyAcute Schizophrenia TreatmentAntipsychotic EfficacyAntipsychotic SafetyBayesian Network Meta-analysisDose-response Network Meta-analysisLow-density Lipoprotein ParticlesNetwork Meta-analysis HeterogeneityPharmacologic Metabolic Effects
Aim: To assess the relative efficacy and metabolic effects of lurasidone and brexpiprazole in the acute treatment of schizophrenia. Methods: Five lurasidone and three brexpiprazole trials were identified. In the absence of head-to-head trials, a Bayesian network meta-analysis comparing lurasidone and brexpiprazole was performed. Results: Nonstatistically significant differences in efficacy measures were observed between lurasidone and brexpiprazole. Significant differences favoring lurasidone for weight change (-0.69 kg; 95% CrI: -1.22 to -0.15), total cholesterol (-7.60 mg/dl; 95% CrI: -13.94 to -1.22), and low-density lipoprotein (-6.58 mg/dl; 95% CrI: -12.11 to -1.04) were observed, with a trend indicating half the risk of experiencing ≥7% weight gain. Conclusion: This network meta-analysis suggested that lurasidone had similar efficacy and fewer metabolic effects than brexpiprazole in patients with acute schizophrenia.
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