Concepedia

pH and reduction-activated polymeric prodrug nanoparticles based on a 6-thioguanine-dialdehyde sodium alginate conjugate for enhanced intracellular drug release in leukemia

Yanming Wan, Ying Bu, Jiaming Liu, Jia Yang, Weiquan Cai, Yihua Yin, Wenjin Xu, Peihu Xu, Jingli Zhang, Meng He

Polymer Chemistry · 2018 · 23 citations · 36 references

DOI

Concepts

Abstract

Synthesis schematics of DSA and 6-TG-DSA as well as processes of PPN self-assembly and its pH/GSH dual stimuli-response release of the conjugated 6-TG.

References

36

Alginate: Properties and biomedical applications

Kuen Yong Lee, David Mooney · Progress in Polymer Science · 2011 · 7.8K citations

, , +11

Induction of differentiation of the human promyelocytic leukemia cell line (HL-60) by retinoic acid.

T. R. Breitman, Stuart E. Selonick, SJ Collins · Proceedings of the National Academy of Sciences · 1980 · 2K citations · Full text

, , +11

Polymer–drug conjugation, recent achievements and general strategies

Gianfranco Pasut, F. M. Veronese · Progress in Polymer Science · 2007 · 608 citations

, , +16

Polymeric Conjugates for Drug Delivery

Nate Larson, Hamidreza Ghandehari · Chemistry of Materials · 2012 · 571 citations · Full text

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Prodrugs Forming High Drug Loading Multifunctional Nanocapsules for Intracellular Cancer Drug Delivery

Youqing Shen, Erlei Jin, Bo Zhang et al. · Journal of the American Chemical Society · 2010 · 566 citations

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