Cohort profile: The Pharmacokinetic and clinical Observations in PeoPle over fiftY (POPPY) study

Abstract

The Pharmacokinetic and clinical Observations in PeoPle over fiftY (POPPY) Study was initiated in 2013 as the first large-scale study to assess clinical outcomes of people living with HIV (PLWH) over the age of 50 in England and Ireland. ] An additional, related, aim of the study is to investigate the impact of age on the concentrations of the different antiretroviral agents in the blood among PLWH. It is hoped that the study findings will contribute to the development and implementation of evidence-based recommendations for the optimal management and clinical monitoring of older PLWH. Study results will also contribute to the design of future studies for the treatment of diseases associated with ageing in this population.