Applied Nanoscience · 2018 · 13 citations · 31 references
Natural SciencesBiomedical EngineeringMaterials ScienceNanomaterialsNanotechnologySurface ScienceCell-nanoparticle InteractionsNanomedicineNanoparticle CharacterizationNanoparticle InterfacesNanoparticle SurfacesQuantum DotsBiomedical ApplicationsCell Attachment AssaysEscherichia ColiLigand ExchangeNano-bio InterfacesNanoparticle-biomolecule InteractionsQuantum Dot Surface ChemistrySurface Potential
Abstract Nano interface influences in physiochemical properties of quantum dots (QDs) are the challenging approach to tailor its surface functionalities. In this study, a set of polar and non-polar solvents were selected to analyze the influences in solvent-based dynamic radius and surface potential of QDs. From the nano interface chemistry of polar and non-polar solvents, an appropriate mechanism of precipitation and hydrophobic ligand exchange strategy were elucidated by correlating Henry’s equation. Further, the in vitro cytotoxic potential and antimicrobial activity of QDs were assessed to perform biolabeling. From the observations, an appropriate dosage of QDs was fixed to label the animal ((RAW 264.7 cell lines) and bacterial cells ( Escherichia coli ) for effective cell attachment. Biolabeling was achieved by tailoring nano interface chemistry of QDs without additional support of biomolecules. Bacterial cell wall-based interaction of QDs was evaluated using SEM and EDAX analysis. Thus, provided clear insights into the nano interface chemistry in the development of highly photostable QDs will be helpful in biomedical applications.
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In vivo cancer targeting and imaging with semiconductor quantum dots
Xiaohu Gao, Yuanyuan Cui, Richard M. Levenson et al. · Nature Biotechnology · 2004 · 4.7K citations