Concepedia

MicroRNA-378 suppresses myocardial fibrosis through a paracrine mechanism at the early stage of cardiac hypertrophy following mechanical stress.

Jie Yuan, Haibo Liu, Wei Gao, Li Zhang, Yong Ye, Lingyan Yuan, Zhiwen Ding, Jian Wu, Le Kang, Xiaoyi Zhang,

Theranostics · 2018 · 172 citations · 28 references

DOIFull text

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Concepts

Abstract

: miR-378 is secreted from cardiomyocytes following mechanical stress and acts as an inhibitor of excessive cardiac fibrosis through a paracrine mechanism.

References

28

MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts

Thomas Thum, Carina Gross, Jan Fiedler et al. · Nature · 2008 · 2.3K citations

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Secretory Mechanisms and Intercellular Transfer of MicroRNAs in Living Cells

Nobuyoshi Kosaka, Haruhisa Iguchi, Yusuke Yoshioka et al. · Journal of Biological Chemistry · 2010 · 1.9K citations · Full text

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Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis

Eva van Rooij, Lillian B. Sutherland, Jeffrey E. Thatcher et al. · Proceedings of the National Academy of Sciences · 2008 · 1.8K citations · Full text

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MicroRNA-133 controls cardiac hypertrophy

Alessandra Carè, Daniele Catalucci, Federica Felicetti et al. · Nature Medicine · 2007 · 1.8K citations

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Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells

Marı́a Mittelbrunn, Cristina Gutiérrez‐Vázquez, Carolina Villarroya‐Beltri et al. · Nature Communications · 2011 · 1.8K citations · Full text

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