Association of increased primary breast tumor<i>AGR2</i>with decreased disease-specific survival

Abstract

Increased primary tumor <i>AGR2</i> expression was associated with decreased DSS. Pathway analyses suggested that increased <i>AGR2</i> was associated with endoplasmic reticular homeostasis, possibly allowing tumor cells to overcome hypoxic stress and meet the increased protein demand of tumorigenesis, thereby preventing unfolded protein response-mediated apoptosis.