Blood Advances · 2018 · 47 citations · 39 references
Life SciencesCell BiologyMolecular BiologyGene ExpressionMolecular Cell BiologyTranscriptional RegulationCis-regulatory ElementsGene Regulatory ElementsDna Binding SpecificityPlasma Cell BiologyZinc Binding ProteinsZinc Finger DomainsZinc Finger MotifsZinc Finger ProteinsZinc Finger Transcription Factors
In contrast, if the zinc finger motif is juxtaposed to the EICE motif, the Ikaros/PU.1/IRF4 complex functioned to activate target gene expression. Our findings revealed a novel mode of IRF4 activity upon PC differentiation where upon forming an Ikaros/IRF4 DNA-bound complex, a subset of genes is repressed.
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BATF–JUN is critical for IRF4-mediated transcription in T cells
Peng Li, Rosanne Spolski, Wei Liao et al. · Nature · 2012 · 465 citations