Concepedia

Proof of concept study of an apoptosis-signal regulating kinase (ASK1) inhibitor (selonsertib) in combination with an acetyl-CoA carboxylase inhibitor (GS-0976) or a farnesoid X receptor agonist (GS-9674) in NASH

Eric Lawitz, Robert Herring, Ziad Younes, Edward Gane, Peter T Ruane, Raul Aguilar Schall, Changku Jia, Rui Xu, B. Mccolgan, Stephen Djedjos,

Journal of Hepatology · 2018 · 11 citations · 0 references

Concepts

MedicineMedicinal ChemistryPharmacologyApoptosisClinical PharmacologyMolecular PharmacologyApoptosis PharmacologyApoptosis RegulationApoptotic SignalingDeath ReceptorsAnti-apoptotic AgentsApoptosis Regulation By KinasesApoptosis-related Kinase CascadesFarnesoid X Receptor AgonistsFarnesoid X Receptor SignalingKinase InhibitorsProtein Kinase Inhibitors