Synthesis of Benzo[4,5]imidazo[2,1‐<i>b</i>]thiazole by Copper(II)‐Catalyzed Thioamination of Nitroalkene with 1<i>H</i>‐Benzo[<i>d</i>]imidazole‐2‐thiol

Abstract

Abstract A Copper(II)‐catalyzed thioamination of β ‐nitroalkene with 1 H ‐benzo[ d ]imidazole‐2‐thiol has been developed for the synthesis of benzo[4,5]imidazo[2,1‐ b ]thiazole derivatives. A variety of N ‐fused benzoimidazothiazole derivatives are obtained in high yields through successive C−N and C−S bond formations. This protocol is also applicable to β ‐substituted β ‐nitroalkenes to afford 2,3‐disubstituted benzoimidazothiazoles. magnified image