Concepedia

Evaluation of the antiparkinsonism and neuroprotective effects of hydrogen sulfide in acute 6-hydroxydopamine-induced animal model of Parkinson’s disease: behavioral, histological and biochemical studies

Mohammad Reza Sarukhani, Hashem Haghdoost-Yazdi, Ali Sarbazi-Golezari, Arvin Babayan-Tazehkand, Tahere Dargahi, Nafiseh Rastgoo

Neurological Research · 2018 · 32 citations · 21 references

DOI

Abstract

Our results show that H<sub>2</sub>S produces significant antiparkinsonism and neuroprotective effects against 6-OHDA neurotoxicity. Since injection of 6-OHDA into MFB produces severe lesion in SN dopaminergic neurons similar to this lesion in the onset of PD in human being, our data recommend H<sub>2</sub>S as potential therapeutic target for treatment of this disease.

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