β-catenin-activated hepatocellular carcinomas are addicted to fatty acids

Abstract

FAO induced by β-catenin oncogenic activation in the liver is the driving force of the β-catenin-induced HCC. Inhibiting FAO by genetic and pharmacological approaches blocks HCC development, showing that inhibition of FAO is a suitable therapeutic approach for <i>CTNNB1</i>-mutated HCC.