Concepedia

Pervasive mutations of JAK-STAT pathway genes in classical Hodgkin lymphoma

Enrico Tiacci, Erik Ladewig, Gianluca Schiavoni, Alex Penson, Elisabetta Fortini, Valentina Pettirossi, Yu‐Chun Wang, Ariele Rosseto, Alessandra Venanzi, Sofija Vlasevska,

Blood · 2018 · 234 citations · 56 references

DOIFull text

Open access

Concepts

Abstract

Key Points Identification of genes frequently mutated in cHL, fostering tumor growth in a manner amenable to pharmacological targeting. Mutated genes include the almost ubiquitous targeting of JAK-STAT pathway members, as well as GNA13, XPO1, and ITPKB.

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