Liquid Chromatography Mass Spectrometry Analysis and Cytotoxicity of <i>Asparagus adscendens</i> Roots against Human Cancer Cell Lines.

Abstract

The MeOH extract and all solid-phase extraction (SPE) fractions exhibited various levels of cytotoxicity against all cell lines with the IC₅₀ values ranging from 6 to 79 μg/mLThe presence of saponins and sapogenins in the SPE fractions was evident in the Liquid chromatography-mass spectrometry dataDue to the presence of saponins and their aglycones, suggest that <i>A. adscendens</i> could be exploited as a potential source of cytotoxic compounds with putative anticancer potential. <b>Abbreviation used:</b> SPE: Solid-phase extraction, MCF7: Breast cancer cell line, HEPG2: Liver cancer cell line, A549: Lung liver cancer cell line, EJ138: Urinary bladder cancer cell line, MTT: 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromide, LC-MS: Liquid chromatography-mass spectrometry.