Preparation and Properties of Janus Heparin-Loaded Ammoniated-Hollow Mesoporous Silica Nanomotors

Abstract

In this case, the development of Janus heparin-loaded ammoniated-hollow mesoporous silica (H-A-HMS) nanomotors was reported. First, A-HMS nanoparticles were prepared by combination of hard template (Fe3O4 regarded as core), soft template (cetyltrimethylammonium bromide (CTAB) regarded as mesoporous template agent) and ammoniated process. Then, the heparin was loaded into A-HMS nanoparticles by a simple soaking process, and Janus H-A-HMS nanomotors were fabricated by platinum (Pt) decorating onto the partial surface of H-A-HMS nanoparticles, which the bubble-propelled motion was obtain by the help of Pt catalytic decomposition of hydrogen peroxide (H2O2) into oxygen (gas) and water. Finally, results of a performance test indicated that the H-A-HMS nanomotors we proposed had good blood compatibility, noncytotoxicity, high load and controlled release of heparin, and autonomous motion ability. They will bring great potential for more applications of heparin in the biomedical field.