Promoter methylation of DNA damage repair (DDR) genes in human tumor entities: RBBP8/CtIP is almost exclusively methylated in bladder cancer

Abstract

<i>RBBP8</i> was identified as almost exclusively hypermethylated in BLCA. <i>RBBP8</i>/CtIP has a proven role in homologous recombination-mediated DNA double-strand break repair known to sensitize cancer cells for PARP1 inhibitors. Since <i>RBBP8</i> methylation was detectable in urines, it may be a complementary marker of high specificity in urine for BLCA detection.