Pd-Catalyzed Decarboxylative Sonogashira Reaction via Decarboxylative Bromination

Abstract

The decarboxylative alkynylation of (hetero)aryl carboxylic acids with terminal alkynes has been achieved by using a Pd(PPh₃)₄/PCy₃ catalyst. This Pd-catalyzed method exhibits good functional group tolerance for both coupling partners and enables chemical modification of complex molecules. The establishment of this decarboxylative alkynylation reaction is attributed to the discovery of a highly selective decarboxylative bromination of (hetero)aryl carboxylic acids with NBS ( N-bromosuccinimide).