Clostridium thermocellum LL1210 pH homeostasis mechanisms informed by transcriptomics and metabolomics

Abstract

<i>Clostridium thermocellum</i> LL1210 can grow under slightly acidic conditions, similar to limits reported for other strains. This foundational study provides a detailed characterization of a relatively acid-intolerant bacterium and provides genetic targets for strain improvement. Future studies should examine adding gene functions used by more acid-tolerant bacteria for improved pH homeostasis at acidic pH values.