EYA4 inhibits hepatocellular carcinoma growth and invasion by suppressing NF‐κB‐dependent RAP1 transactivation

Abstract

Our findings provide a functional and mechanistic basis for identifying EYA4 as a bona fide tumor suppressor that disrupts aberrant activation of the NF-κB/RAP1 signaling pathway and thus orchestrates a physiological impediment to HCC growth and invasion.