Skeletal Rearrangements as Strategies for the Total Syntheses of Indole Alkaloids

Abstract

In this account, we summarize our recent efforts in the total syntheses of several indole alkaloids, including minfiensine, calophyline A, deformylcorymine, strictamine, and goniomitine. Our central theme is to utilize skeletal rearrangements as key strategies for generating complex structures. 1 Introduction 2 The Development of an Aza-Pinacol Rearrangement 3 Applications of Aza-Pinacol Rearrangements in Total ­Syntheses 4 Strategy Extension: The Total Synthesis of Goniomitine 5 Conclusion