Immunology and Cell Biology · 1963 · 19 citations · 0 references
Life SciencesBiochemistryChemistryMolecular VirologyPhysical ChemistryVirologyAntiviral PharmacologyHost-virus InteractionsViral AttachmentViral InfectionsVirus StructureVirus-host InteractionsAntiviral Mechanisms Of ActionAntiviral Structure-activity RelationshipsStructural Basis Of AntigenicityViral Adsorption KineticsViral Surface ProteinsVirus AdsorptionVirus Inactivation Mechanisms
SUMMARY Some metal chelates of substituted 1, 10‐phenanthrolines inactivate the infectivity of certain viruses. Other viral properties, including haemagglutination, antigenicity and the capacity to adsorb to host cells, are also affected, though to a lesser extent. The interaction between virus and chelate is partly reversible, since the haemagglutinating capacity of treated virus can be restored by washing. The relation between chemical structure and activity of various chelates as well as the sensitivity of viruses of differing chemical constitution, indicates that the chelates act purely physically following adsorption to the viral surface.