Protective Role of mPGES-1 (Microsomal Prostaglandin E Synthase-1)–Derived PGE <sub>2</sub> (Prostaglandin E <sub>2</sub> ) and the Endothelial EP4 (Prostaglandin E Receptor) in Vascular Responses to Injury - Concepedia

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Protective Role of mPGES-1 (Microsomal Prostaglandin E Synthase-1)–Derived PGE <sub>2</sub> (Prostaglandin E <sub>2</sub> ) and the Endothelial EP4 (Prostaglandin E Receptor) in Vascular Responses to Injury

DOI Full Paper Access

28

Citations

30

References

2018

Year

Huifeng Hao, Sheng Hu, Qing Wan, Chuansheng Xu, Hong Chen, Liyuan Zhu, Zhenyu Xu, Jian Meng, Richard Breyer, Nailin Li,

Arteriosclerosis Thrombosis and Vascular Biology

Abstract

Removal of the IP receptors unmasks a protective role of mPGES-1-derived PGE<sub>2</sub> in limiting injury-induced vascular hyperplasia. EP4, in the endothelial compartment, is essential to promote reendothelialization and restrain neointimal formation after injury. Activating EP4 bears therapeutic potential to prevent restenosis after percutaneous coronary intervention.

References

	Year	Citations

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