Effects of Dahuang zhechong pill on doxorubicin-resistant SMMC-7721 xenografts in mice

Abstract

DHZCP inhibited the growth of DOX-resistant hepatocellular carcinoma subcutaneous xenografts in nude mice and promoted increased apoptosis caused by DOX, thus reversing DOX resistance. This was associated with a decline in energy metabolism and regulated expression of pro-apoptotic proteins.