New Eudesmane-Type Sesquiterpenoids from the Mangrove-Derived Endophytic Fungus Penicillium sp. J-54

Abstract

Four new eudesmane-type sesquiterpenoids, penicieudesmol A-D (<b>1</b>-<b>4</b>), were isolated from the fermentation broth of the mangrove-derived endophytic fungus <i>Penicillium</i> sp. J-54. Their structures were determined by spectroscopic methods, the in situ dimolybdenum CD method, and modified Mosher's method. The bioassays results showed that <b>2</b> exhibited weak cytotoxicity against K-562 cells.