Isochlorogenic Acid C Reverses Epithelial–Mesenchymal Transition via Down-regulation of EGFR Pathway in MDA-MB-231 cells

Abstract

These results suggested that the inhibitory effects of ICAC against EGFR-induced EMT and MDA-MB-231 cell invasion were dependent on the EGFR/ phospholipase Cγ (PLCγ)/extracellular regulated protein kinase ½ (ERK½)/slug signaling pathway. Therefore, the obtained results could provide us clues for the next therapeutic strategy in the treatment of TNBC.