Concepedia

Publication | Open Access

Cerebellar α<sub>6</sub>‐subunit‐containing GABA<sub>A</sub>receptors: a novel therapeutic target for disrupted prepulse inhibition in neuropsychiatric disorders

DOIFull Paper Access

32

Citations

54

References

2018

Year

Lih‐Chu Chiou, Hsin‐Jung Lee, Margot Ernst, Wei‐Jan Huang, Jui‐Feng Chou, H.-W. Chen, Akihiro Mouri, Liang‐Chieh Chen, Marco Treven, Takayoshi Mamiya,
British Journal of Pharmacology

Abstract

Positive allosteric modulation of cerebellar α<sub>6</sub> GABA<sub>A</sub> receptors rescued disrupted PPI by attenuating granule cell activity. α<sub>6</sub> GABA<sub>A</sub> receptor-selective PAMs are potential medicines for treating sensorimotor gating deficits in neuropsychiatric disorders. A mechanistic hypothesis is based on evidence for cerebellar contributions to cognitive functioning including sensorimotor gating.

References

YearCitations

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