Organic Letters · 2018 · 38 citations · 51 references
Palladium-catalyzed Domino Cyclization/alkylationChemical EngineeringTerminal AlkynesQuarternary Carbon CenterFerrocene AcetyleneEngineeringAlkene MetathesisCross-coupling ReactionAir Atmosphere ConditionsOrganic ChemistryAlkynyl-functionalized Azaindoline DerivativesOrganometallic CatalysisCatalysisChemistryAsymmetric CatalysisSynthetic ChemistryEnantioselective SynthesisBiomolecular Engineering
A novel palladium-catalyzed domino cyclization/alkylation of terminal alkynes was achieved for the synthesis of alkynyl-functionalized 3,3-disubstituted azaindoline derivatives under air atmosphere conditions. Various types of terminal alkynes, including aromatic alkynes, aliphatic alkynes, and ferrocene acetylene, can undergo the process successfully. The protocol provides a range of alkynyl-functionalized azaindoline scaffolds bearing a quarternary carbon center.
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Enantio- and Diastereodivergent Dual Catalysis: α-Allylation of Branched Aldehydes
Simon Krautwald, David Šarlah, Michael A. Schafroth et al. · Science · 2013 · 913 citations