Red blood cells treated with the amustaline (S‐303) pathogen reduction system: a transfusion study in cardiac surgery

Abstract

Amustaline-treated RBCs demonstrated equivalence to control RBCs for Hb content, have appropriate characteristics for transfusion, and were well tolerated when transfused in support of acute anemia. Renal impairment was characterized as a potential efficacy endpoint for pivotal studies of RBC transfusion in cardiac surgery.