<i>In vivo</i>and<i>in vitro</i>identification of<i>Z</i>-BOX C – a new bilirubin oxidation end product

Abstract

A new bilirubin oxidation end product (BOX) was isolated and characterized. The formation of the so-called Z-BOX C proceeds from bilirubin via propentdyopents as intermediates. This BOX was detected in pathological human bile samples using liquid chromatography/mass spectrometry and has potential relevance for liver dysfunction and cerebral vasospasms.