Microwave‐Assisted Synthesis of Imidazoquinazoline for Chemosensing of Pb ²⁺ and Fe ³⁺ and Living Cell Application

Abstract

Abstract An efficient dual‐responsive fluorescent probe based on imidazoquinazoline has been synthesised using microwave‐assisted solvent‐free condition. Its sensing behaviour towards Pb 2+ and Fe 3+ has been investigated separately through fluorescence, absorbance and visual fluorescence colour changes in different solvent systems. Interestingly, the binding event triggers selective “turn‐on” response to Pb 2+ and ratiometric response to Fe 3+ against other commonly coexistent metal ions. The observed experimental data has been rationalized in terms of theoretical calculations. The living cell imaging experiment demonstrated the practical value of the sensor in mapping intracellular Fe 3+ and Pb 2+ distributions in biological systems.