Incapacity to control emotion in major depression may arise from disrupted white matter integrity and <scp>OFC</scp>‐amygdala inhibition

Abstract

Our findings suggest that pathways connecting these two nodes may be core targets of the antidepressant treatment. In particular, it raised the intriguing question: Does the reversal of structural markers of connectivity reflect a response to antidepressant medication or activity-dependent myelination following a therapeutic restoration of effective connectivity?