Anti-inflammatory activities of the chemical constituents isolated from <i>Trametes versicolor</i>

Abstract

Twenty-seven compounds including nine triterpenoids (<b>1</b>-<b>9</b>), eight sterols (<b>10</b>-<b>17</b>), two ribonucleotides (<b>18</b>, <b>19</b>), four phenols (<b>20</b>-<b>23</b>), three glycosides (<b>24</b>-<b>26</b>), and one furan (<b>27</b>) were isolated from the fruiting bodies of <i>Trametes versicolor</i> (L.) Lloyd. This study is the first confirmation of the presence of the 11 compounds (<b>3</b>, <b>5</b>, <b>6</b>, <b>8</b>, <b>18</b>, <b>20</b>, <b>21</b>, <b>23</b>-<b>25</b>, and <b>27</b>) isolated from the Polyporaceae family, with six of these (<b>2</b> and <b>12</b>-<b>16</b>) from the genus <i>Trametes</i>. Compounds <b>3</b>, <b>4</b>, <b>10</b>, <b>11</b>, <b>16</b> and <b>17</b> were found to significantly inhibit the production of NO, TNF-α and IL-6 in a dose-dependent manner.