Effect of immediate and prolonged GLP‐1 receptor agonist administration on uric acid and kidney clearance: <i>Post‐hoc</i> analyses of four clinical trials

Abstract

Immediate exenatide infusion increases UE_UA in overweight healthy men and in T2DM patients, probably by inhibiting Na⁺ /H⁺ -exchanger type-3 in the renal proximal tubule. Prolonged treatment with a long-acting or short-acting GLP-1RA does not affect plasma UA or UE_UA in T2DM patients with normal plasma UA levels and at relatively low cardiovascular risk. Our results suggest that the cardio-renal benefits of GLP-1RA are not mediated through changes in UA.