Atovaquone Impairs Growth of <i>Aspergillus</i> and <i>Fusarium</i> Keratitis Isolates by Modulating Mitochondrial Function and Zinc Homeostasis

Abstract

These studies demonstrate that atovaquone has pronounced in vitro and in vivo antifungal activity against filamentous fungi by disrupting both metal homeostasis and mitochondrial function, and therefore has potential as a novel antifungal agent.