Identification of the acid‐induced degradation products of omeprazole and 5‐hydroxyomeprazole by high‐resolution mass spectrometry

Abstract

The resultant degradants from omeprazole and 5-hydroxyomeprazole were analogous to each other, differing only by an oxygen atom. This investigation determined the degradation products of omeprazole and 5-hydroxyomeprazole and proposed structures based on the accurate mass and isotope information. The product ions from the degradation products are also reported.