Concepedia

Epothilone B Benefits Nigrostriatal Pathway Recovery by Promoting Microtubule Stabilization After Intracerebral Hemorrhage

Yang Yang, Xuan Zhang, Hongfei Ge, Wei Liu, Eryi Sun, Yuanyuan Ma, Hengli Zhao, Rongwei Li, Weixiang Chen, Jichao Yuan,

Journal of the American Heart Association · 2018 · 39 citations · 31 references

DOIFull text

Open access

Abstract

Our results clarified the pathomorphological changes of the nigrostriatal pathway after ICH and found that epothilone B helped alleviate nigrostriatal pathway injury after ICH, associated with promoting α-tubulin acetylation to maintain microtubule stabilization, thus facilitating motor recovery.

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