Fabrication and evaluation of ultra deformable vesicles for atopic dermatitis as topical delivery

Abstract

The objective of present investigation was to formulate hydrogel containing glycyrrhizic acid loaded Ultra deformable vesicles i.e., transfersomes effective against atopic dermatitis. These were formulated using thin film hydration technique and this transferosomal suspension was loaded into a hydrogel base. This was characterized on the basis of parameters like particle size, shape and surface morphology, in vitro release, in vivo studies and skin deposition studies. The optimized formulation showed the in vitro release of 89.8% upto 24 h and following Higuchi’s equation (R2 = 0.971).The data obtained revealed that the formulation is able to be effective against atopic dermatitis.