Clinical and Microbiological Characteristics of Candida guilliermondii and Candida fermentati

Abstract

A total of 46 clinical isolates of <i>Candida guilliermondii</i> and <i>Candida famata</i> were reidentified genetically, resulting in 27 <i>C. guilliermondii</i> and 12 <i>Candida fermentati</i> strains. The majority of <i>C. guilliermondii</i> strains, but not <i>C. fermentati</i> strains, were isolated from blood cultures. <i>C. fermentati</i> was more sensitive to antifungals, hydrogen peroxide, and killing by murine macrophages than was <i>C. guilliermondii</i> The <i>C. guilliermondii</i> isolates were echinocandin susceptible <i>in vitro</i> but resistant to micafungin in a murine model of invasive candidiasis.