THE EFFECT OF COPROCESSED SUPERDISINTEGRANTS RATIO (CROSPOVIDONE-SODIUM STARCH GLYCOLATE) TO THE PHYSICOCHEMICAL CHARACTERISTICS OF ATENOLOL ORALLY DISINTEGRATING TABLETS

Abstract

Objective: The objective of this study was to evaluate the effect of coprocessed superdisintegrants (crospovidone-sodium starch glycolate) ratio 1:1; 1:2; and 1:3 to the physicochemical characteristics of atenolol orally disintegrating tablets.Methods: Orally disintegrating tablets of atenolol were prepared by direct compression method. There were three formulas which using three different ratios of coprocessed superdisintegrants (crospovidone-sodium starch glycolate). The ratio of coprocessed superdisintegrants were, 1:1 (formula 1); 1:2 (formula 2); and 1:3 (formula 3). Evaluation of the formulas was conducted before compression (pre-compression evaluation) and after compression (post-compression evaluation).Results: The results of pre-compression evaluation showed that all the formulas have good flowability and excellent angle of repose. The results of post-compression evaluation showed that all the formulas met the specification of orally disintegrating tablets. The different ratio of coprocessed crospovidone-sodium starch glycolate (1:1; 1:2; and 1:3) caused significant differences in tablet dispersion time (p<0.05). Dissolution test showed that all the formulas met the specification of dissolution from atenolol tablet (not <85% of atenolol was dissolved in 30 min). Formula 1 showed the highest dissolution efficiency (92.91±0.11)% and area under the curve value (11149.13±13.15) compared to formula 2 and formula 3.Conclusion: The results from this study showed that coprocessed superdisintegrants (crospovidone-sodium starch glycolate) ratio affect the physicochemical characteristics of atenolol orally disintegrating tablet. Based on pre-compression evaluation and post-compression evaluation, formula 1 was the best formula.