Differences in trait impulsivity do not bias the response to pharmacological drug challenge in the rat five-choice serial reaction time task

Abstract

Our findings indicate that different pharmacological challenges increase impulsivity on the 5-CSRTT, with modest effects on attention. These effects were not influenced by underlying differences in impulsivity phenotype, which is an important prerequisite to reliably use these challenge models to screen and profile compounds with putative anti-impulsive characteristics.