Levels of Cytokines and Micro<scp>RNA</scp>s in Individuals With Asymptomatic Hyperuricemia and Ultrasonographic Findings of Gout: A Bench‐to‐Bedside Approach

Abstract

In individuals with chronic asymptomatic hyperuricemia, the presence of synovitis and double contour sign by US may represent a subclinical manifestation of monosodium urate crystal nucleation, capable of triggering inflammatory pathways (IL-6 and IL-8) and mechanisms of intercellular communication (miR-155), similar to what is observed in patients with gout.