Comparative Evaluation of Using NOTA and DOTA Derivatives as Bifunctional Chelating Agents in the Preparation of ⁶⁸ Ga-Labeled Porphyrin: Impact on Pharmacokinetics and Tumor Uptake in a Mouse Model

Abstract

The present study demonstrates that the pharmacokinetic behavior of ⁶⁸Ga-labeled porphyrin derivatives, prepared using either NOTA or DOTA derivatives as BFCAs, remains almost identical and hence both NOTA and DOTA derivatives could be considered equivalent for developing ⁶⁸Ga-based PET agents for imaging of tumorous lesions.