Catalytic Asymmetric β-C–H Functionalizations of Ketones via Enamine Oxidation

Abstract

A chiral primary amine catalyzed oxidative β-C-H functionalization of ketone is described. The reaction proceeds via ketone enamine oxidation by IBX and enables highly enantioselective remote C-H functionalization of both cyclic and acyclic ketones, generating chiral ketones bearing β-stereocenters.