LIVER TRANSPLANTATION AND LIVER RESECTION WITH VASCULAR RECONSTRUCTION FOR ADVANCED ALVEOCOCCOSIS

Abstract

Aim. To study the results of liver transplantations and resections with vascular reconstruction for advanced alveococcosis. Material and Methods. The retrospective study included 21 patients with alveococcosis and lesion of more than 5 segments and (or) a parasitic invasion into portal vein bifurcation and (or) inferior vena cava, and (or) hepaticocaval confluence. Results. Liver resection was performed in 9 (42.9%) patients (group 1) if preserving or reconstruction of afferent and (or) efferent venous bed of remaining liver part was technically feasible. Hypothermic perfusion in vivo in situ was used in 1 case, portal vein reconstruction — in 5 cases, inferior vena cava reconstruction — in 8 patients, arterial reconstruction — in 1 patient. Transplantation was performed in 12 (57.1%) patients (group 2). There were 6 patients with liver cirrhosis and 1 patient with Budd-Chiari syndrome. The whole liver from postmortem donors was transplanted to 7 recipients, right liver half from living related donors — to 5 patients. Inferior vena cava resection was performed in 10 cases. Hospital mortality was absent. Median recurrence-free follow-up was 17 months. Overall 1- and 3-year survival was 100% and 89%, respectively (p = 0.617). Conclusion. Radical treatment of advanced liver alveococcosis is feasible in the most of patients if unresectable distant metastases are absent and initial surgical tactics is correct. Interventions should be performed in specialized centers where resections and transplantations are routinely performed.