Concepedia

Potent dialkyl substrate-product analogue inhibitors and inactivators of α-methylacyl-coenzyme A racemase from Mycobacterium tuberculosis by rational design

Mohan Pal, Nicole M. Easton, Hannah Yaphe, Stephen L. Bearne

Bioorganic Chemistry · 2018 · 12 citations · 49 references

Concepts

Antimicrobial Drug DiscoveryBiochemistryRational DesignMedicineMycobacterium TuberculosisTuberculosisAntibacterial Agentα-Methylacyl-coenzyme A RacemaseAntimicrobial ChemotherapyAntimicrobial CompoundPharmacologyDrug Discovery

References

49

A method for the quantitative recovery of protein in dilute solution in the presence of detergents and lipids

D. Wessel, U.I. Flügge · Analytical Biochemistry · 1984 · 4.1K citations

Protein Chemistry, Engineering, Biochemistry +11

NMR Chemical Shifts of Common Laboratory Solvents as Trace Impurities

Hugo E. Gottlieb, Vadim Kotlyar, Abraham Nudelman · The Journal of Organic Chemistry · 1997 · 3.6K citations

Engineering, Chemical Analysis, Magnetic Resonance +16

Esters of Methanesulfonic Acid as Irreversible Inhibitors of Acetylcholinesterase

Richard J. Kitz, Irwin B. Wilson · Journal of Biological Chemistry · 1962 · 1.5K citations · Full text

Medicinal Chemistry, Pharmaceutical Chemistry, Biochemistry +5

Evaluation of enzyme inhibitors in drug discovery. A guide for medicinal chemists and pharmacologists.

Robert A. Copeland · PubMed · 2005 · 1.1K citations

Target Enzyme, Drug Target, Pharmacotherapy +20

α-Methylacyl Coenzyme A Racemase as a Tissue Biomarker for Prostate Cancer

Mark A. Rubin · JAMA · 2002 · 640 citations