The α2 isoform Na,K‐ATPase modulates contraction of rat mesenteric small artery via cSrc‐dependent Ca²⁺ sensitization

Abstract

Data suggest that micromolar ouabain potentiates agonist-induced contraction of rat mesenteric small artery via Na,K-ATPase-dependent cSrc activation, which increases Ca²⁺ sensitization of vascular smooth muscle cells by MYPT1 phosphorylation. This mechanism may be critical for acute control of vascular tone.