High prevalence of <i>Helicobacter pylori</i> clarithromycin resistance mutations among Seattle patients measured by droplet digital <scp>PCR</scp>

Abstract

The prevalence of clarithromycin resistance detected in this region exceeds 20%, indicating that standard triple therapy should not be the first-line antibiotic treatment for H. pylori infection. Culture-free assays for detecting clarithromycin resistance mutations can be performed on archived tissue samples and will aid in informing tailored treatment for effective H. pylori eradication.