Antidiabetic, cytotoxic and antioxidant activities of oil extracted from <i>Acrocomia aculeata</i> pulp

Abstract

This study evaluated the hypoglycemic effect of the oil extracted from the <i>Acrocomia aculeata</i> pulp (OPAC) in normoglycemic rats and streptozotocin (STZ), fructose-induced diabetic rat models and its <i>in vitro</i> antioxidant and cytotoxic potential. OPAC (3, 30 <i>or</i> 300 mg/kg, v.o.) significantly decreased (<i>p</i> < 0.05) the high glucose levels induced by a high fructose-diet in rats. Persistent treatment with OPAC for 24 days also reduced the high plasmatic glucose induced by STZ. In normoglycemic animals, OPAC significantly decreased glucose levels. While <i>A. aculeata</i> oil exhibited good <i>in vitro</i> antioxidant activity, no sign of cytotoxicity was observed in LLC-PK1 cells (5-500 μg/mL). OPAC has antidiabetic and antioxidant activities without causing <i>in vitro</i> cytotoxicity.