LncRNA <i>ZFAS1</i> as a SERCA2a Inhibitor to Cause Intracellular Ca ²⁺ Overload and Contractile Dysfunction in a Mouse Model of Myocardial Infarction

Abstract

<i>ZFAS1</i> is an endogenous SERCA2a inhibitor, acting by binding to SERCA2a protein to limit its intracellular level and inhibit its activity, and a contributor to the impairment of cardiac contractile function in MI. Therefore, anti-<i>ZFAS1</i> might be considered as a new therapeutic strategy for preserving SERCA2a activity and cardiac function under pathological conditions of the heart.