Downregulation of L‐Type Voltage‐Gated Ca ²⁺ , Voltage‐Gated K ⁺ , and Large‐Conductance Ca ²⁺ ‐Activated K ⁺ Channels in Vascular Myocytes From Salt‐Loading Offspring Rats Exposed to Prenatal Hypoxia

Abstract

The results demonstrated that chronic prenatal hypoxia may program salt-sensitive hypertension in male offspring, providing new information of ion channel remodeling in hypertensive myocytes. This information paves the way for early prevention and treatments of salt-induced hypertension related to developmental problems in fetal origins.