Cardiac Kir2.1 and Na <sub>V</sub> 1.5 Channels Traffic Together to the Sarcolemma to Control Excitability - Concepedia

Concepedia

Publication | Open Access

Cardiac Kir2.1 and Na <sub>V</sub> 1.5 Channels Traffic Together to the Sarcolemma to Control Excitability

DOI Full Paper Access

105

Citations

46

References

2018

Year

Daniela Ponce‐Balbuena, Guadalupe Guerrero‐Serna, Carmen R. Valdivia, Ricardo Caballero, F. Javier Dı́ez-Guerra, Eric N. Jiménez‐Vázquez, Rafael J. Ramírez, André Monteiro da Rocha, Todd J. Herron, Katherine Campbell,

Circulation Research

Abstract

The Na<sub>V</sub>1.5-Kir2.1 macromolecular complex pre-assembles early in the forward trafficking pathway. Therefore, disruption of Kir2.1 trafficking in cardiomyocytes affects trafficking of Na<sub>V</sub>1.5, which may have important implications in the mechanisms of arrhythmias in inheritable cardiac diseases.

References

	Year	Citations

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